Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil.
Identifieur interne : 004D82 ( Main/Exploration ); précédent : 004D81; suivant : 004D83Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil.
Auteurs : Marina F S. Cartaxo [Brésil] ; Constância F J. Ayres ; David WeetmanSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 1878-3503 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Culex.
- épidémiologie : Brésil, Filariose lymphatique.
- Animaux, Densité de population, Dérive génétique, Filariose lymphatique, Fréquence d'allèle, Humains, Lutte contre les moustiques, Mutation, Répétitions microsatellites, Variation génétique.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Brazil.
- epidemiology : Elephantiasis, Filarial.
- genetics : Culex.
- prevention & control : Elephantiasis, Filarial.
- Animals, Gene Frequency, Genetic Drift, Genetic Variation, Humans, Microsatellite Repeats, Mosquito Control, Mutation, Population Density.
Abstract
Recife is one of the largest cities in north-eastern Brazil and is endemic for lymphatic filariasis transmitted by Culex quinquefasciatus. Since 2003 a control program has targeted mosquito larvae by elimination of breeding sites and bimonthly application of Bacillus sphaericus. To assess the impact of this program on the local vector population we monitored the genetic diversity and differentiation of Cx. quinquefasciatus using microsatellites and a B. sphaericus-resistance associated mutation (cqm1(REC)) over a 3-year period. We detected a significant but gradual decline in allelic diversity, which, coupled with subtle temporal genetic structure, suggests a major impact of the control program on the vector population. Selection on cqm1(REC) does not appear to be involved with loss of neutral diversity from the population, with no temporal trend in resistant allele frequency and no correlation with microsatellite differentiation. The evidence for short-term genetic drift we detected suggests a low ratio of effective population size: census population size for Cx. quinquefasciatus, perhaps coupled with strong geographically-restricted population structure. Spatial definition of populations will be an important step for success of an expanded vector control program.
DOI: 10.1016/j.trstmh.2011.05.004
PubMed: 21737112
Affiliations:
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Ayres</name></author><author><name sortKey="Weetman, David" sort="Weetman, David" uniqKey="Weetman D" first="David" last="Weetman">David Weetman</name></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="eISSN">1878-3503</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brazil (epidemiology)</term><term>Culex (genetics)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Gene Frequency</term><term>Genetic Drift</term><term>Genetic Variation</term><term>Humans</term><term>Microsatellite Repeats</term><term>Mosquito Control</term><term>Mutation</term><term>Population Density</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Brésil (épidémiologie)</term><term>Culex (génétique)</term><term>Densité de population</term><term>Dérive génétique</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (épidémiologie)</term><term>Fréquence d'allèle</term><term>Humains</term><term>Lutte contre les moustiques</term><term>Mutation</term><term>Répétitions microsatellites</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Brazil</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Culex</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Culex</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Brésil</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Frequency</term><term>Genetic Drift</term><term>Genetic Variation</term><term>Humans</term><term>Microsatellite Repeats</term><term>Mosquito Control</term><term>Mutation</term><term>Population Density</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Densité de population</term><term>Dérive génétique</term><term>Filariose lymphatique</term><term>Fréquence d'allèle</term><term>Humains</term><term>Lutte contre les moustiques</term><term>Mutation</term><term>Répétitions microsatellites</term><term>Variation génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recife is one of the largest cities in north-eastern Brazil and is endemic for lymphatic filariasis transmitted by Culex quinquefasciatus. Since 2003 a control program has targeted mosquito larvae by elimination of breeding sites and bimonthly application of Bacillus sphaericus. To assess the impact of this program on the local vector population we monitored the genetic diversity and differentiation of Cx. quinquefasciatus using microsatellites and a B. sphaericus-resistance associated mutation (cqm1(REC)) over a 3-year period. We detected a significant but gradual decline in allelic diversity, which, coupled with subtle temporal genetic structure, suggests a major impact of the control program on the vector population. Selection on cqm1(REC) does not appear to be involved with loss of neutral diversity from the population, with no temporal trend in resistant allele frequency and no correlation with microsatellite differentiation. The evidence for short-term genetic drift we detected suggests a low ratio of effective population size: census population size for Cx. quinquefasciatus, perhaps coupled with strong geographically-restricted population structure. Spatial definition of populations will be an important step for success of an expanded vector control program.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Pernambuco</li></region></list><tree><noCountry><name sortKey="Ayres, Constancia F J" sort="Ayres, Constancia F J" uniqKey="Ayres C" first="Constância F J" last="Ayres">Constância F J. Ayres</name><name sortKey="Weetman, David" sort="Weetman, David" uniqKey="Weetman D" first="David" last="Weetman">David Weetman</name></noCountry><country name="Brésil"><region name="Pernambuco"><name sortKey="Cartaxo, Marina F S" sort="Cartaxo, Marina F S" uniqKey="Cartaxo M" first="Marina F S" last="Cartaxo">Marina F S. 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